Anti-Inflammatory Properties of CBD
Many people who suffer from chronic inflammatory conditions, such as arthritis and irritable bowel syndrome, struggle to find relief from conventional medical treatments. Medications that treat inflammatory conditions may come with significant side effects as well, leading people to seek out natural relief for their ailments, such as CBD oil.
Find out all you need to know about CBD and its anti-inflammatory properties.
Anti-Inflammatory Properties of CBD
CBD is short for cannabidiol, an active compound found in the cannabis plant. CBD is extracted from hemp, a type of cannabis that contains only small traces of tetrahydrocannabinol (THC), the active ingredient that creates the "high" associated with marijuana use. Unlike THC, CBD doesn't have any psychoactive effects. It also shows no indication of abuse or dependence potential, according to the World Health Organization.
CBD products such as oils, tinctures, and creams are no longer classified as Schedule I drugs under the federal Controlled Substances Act. Each state has its own laws and regulations legalizing CBD products with different restrictions, though the federal government still considers CBD to be in the same class as marijuana.
Now that it's widely available, CBD is being used to treat everything from acne to anxiety to the side effects of cancer treatments. More research is needed to verify the efficacy of CBD oil for pain management and anti-inflammatory conditions, but early research and anecdotal evidence are promising.
CBD Side Effects
CBD is generally well-tolerated by most people, but it can have side effects like irritability, nausea, and fatigue. It can also affect certain drugs, such as the blood thinner Coumadin. Another concern with CBD is quality control. CBD is marketed as a supplement, not a medication, so it doesn't have the same stringent labeling and content guidelines from the Federal Drug Administration. In addition, some CBD products may be contaminated by chemicals, pesticides, or other pollutants during the growth or extraction process, especially if it's not produced in the United States. There's also no known therapeutic dose for any particular condition.
Medical Conditions With Inflammation
Inflammation is a natural immune process that's designed to protect you from infection. Common inflammation symptoms including swelling, redness, pain, stiffness, and pus discharge. If you've ever had a cut or sprain, you're likely familiar with the relatively mild and transient symptoms of acute inflammation.
Chronic inflammation is a different story. Chronic inflammation is long-term inflammation that lasts for prolonged periods, usually months or years. This occurs as a result of many conditions, such as acute inflammation from bacteria, fungi, or other parasites that aren't properly eliminated; long-term exposure to irritants or foreign materials; autoimmune disorders that attack healthy tissue; cellular defects that cause recurrent inflammation; and recurrent episodes of acute inflammation.
Currently, the World Health Organization considers chronic inflammatory diseases as the greatest threat to human health. In 2014, the Rand Corporation found that nearly 60% of Americans had at least one chronic condition, 42% of Americans had more than one chronic condition, and 12% of Americans had five or more chronic conditions.
Here are some of the most prominent chronic inflammatory conditions:
Diabetes mellitus is a group of diseases that affect the way the body processes blood sugar (glucose). Glucose is a necessary source of energy for the cells of the muscles, brain, and other tissue. The types of diabetes all have different causes, but the overarching issue is that excess glucose builds up in the blood, leading to other health problems.
Chronic diabetes includes Type 1 and Type 2 diabetes. Pre-diabetes, which is indicated by a higher-than-normal level of blood glucose, is a precursor to diabetes and is reversible.
Diabetes symptoms include opportunistic infections, fatigue, blurred vision, slow-healing wounds, excessive thirst and hunger, and a buildup of ketones, which occur when the muscles and fat break down from the absence of insulin.
Over time, diabetes can lead to complications like kidney damage, eye damage, nerve damage, cardiovascular disease, skin infections, hearing loss, Alzheimer's disease, and foot damage. In severe cases, diabetes can lead to blindness, amputation, heart attack, stroke, and kidney failure.
Cardiovascular diseases are a group of disorders of the heart and blood vessels. They include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, congenital heart disease, and deep vein thrombosis. Cardiovascular diseases can lead to acute events such as heart attack and stroke.
Many lifestyle choices increase the risk of cardiovascular diseases, such as unhealthy diet, sedentary lifestyle, overconsumption of alcohol, and tobacco use. These can lead to a systemic inflammatory state, which increases the risk of cardiovascular disease and its associated complications.
Arthritis and Joint Conditions
Arthritis is a group of joint diseases. There are over 100 types of arthritis and joint conditions that can affect different ages, races, and genders. Common arthritis affects the joints and causes swelling, pain, and stiffness, which may range from mild to severe.
The types of arthritis are grouped into the following categories:
- Degenerative Arthritis: Osteoarthritis is the most common type of arthritis and occurs when the cartilage within the joints wears away, leaving bone to rub against bone.
- Inflammatory Arthritis: Rheumatoid arthritis, psoriatic arthritis, gout, and ankylosing spondylitis are types of inflammatory arthritis, which is when the immune system mistakenly attacks the joints with uncontrolled inflammation. Inflammatory arthritis can be disfiguring and debilitating over time as joints deteriorate.
- Infectious Arthritis: Infectious arthritis is caused by bacteria, viruses, or fungi that attack the joints, such as salmonella, Lyme, chlamydia, hepatitis C and shigella. Cases typically resolve with prompt treatment, but arthritis can become chronic.
- Metabolic Arthritis: Gout is a type of metabolic arthritis that occurs when uric acid levels are excessive, forming needle-like crystals within the joint. Gout is episodic, but it's usually recurrent if the uric acid levels are managed.
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS), is a disorder that affects the large intestine and creates symptoms like abdominal pain, bloating, gas, cramping, constipation, and diarrhea. IBS is a chronic condition that needs to be managed long-term with lifestyle changes, diet, medication, and stress-management techniques. Though not life-threatening, IBS can lead to quality of life issues and mood disorders in sufferers.
Anti-Inflammatory Properties of CBD
CBD research has shown promise in treating and managing inflammation. It works through a variety of mechanisms, including:
- Prostaglandins: CBD is effective at relieving certain types of inflammation because it inhibits COX-2, the enzyme responsible for making inflammatory prostaglandins.
- Tumor Necrosis Factor (TNF): In rodent studies, CBD was effective at protecting joints against damaging inflammation from arthritis. This is believed to be a result of CBD's ability to reduce the production of inflammatory tumor necrosis factor.
- PPARγ: CBD showed therapeutic potential for stimulating PPARγ, which alters the gene expression in your DNA and reduces the production of inflammatory molecules. This application could be beneficial for multiple sclerosis, ulcerative colitis, Alzheimer's disease, and more.
- Endocannabinoid System: The body's natural endocannabinoid system regulates many functions within the body, including sleep, appetite, pain, and immune response. These neurotransmitters bind to cannabinoid receptors in the nervous system. Studies show that CBD may impact the endocannabinoid receptor activity, reducing inflammation.
Treating Inflammation With CBD
It's clear that CBD has enormous potential to help patients struggling with inflammatory conditions, but the lack of clinical research leaves a gray area regarding what forms and dosages of CBD will be effective, and for which patients. Fortunately, CBD is generally safe, and side effects are rare, but even when they occur, they're generally mild.
Here are some things to keep in mind when choosing CBD as a therapeutic option for treating inflammation:
- CBD is not a substitute for the clinical treatment of some inflammatory diseases
- You should work with a physician to discuss potential drug interactions, dosage, and results
- Choose quality CBD products for better results and lower risk of contamination
With its minimal risks and side effects, promising research, and further clinical research on the way, CBD is a great option for managing inflammatory conditions. If you're considering CBD for your arthritis, IBS, or other inflammatory conditions, it's important to choose the highest-quality option for the best therapeutic potential.
Hydration, CBD, and Inflammation
Dehydration is another huge factor when talking about treating inflammation. When you are properly hydrated, your body can more easily flush toxins out of your body, which in turn can help fight inflammation.
That’s why the team at Buoy Hydration made Buoy + CBD. A hydration + CBD boost that also contains a nearly tasteless nano-emulsified, hemp-based, water-soluble CBD. Take your battle against inflammation to the next level by hydrating with the power of CBD.
Anti-inflammatory properties, Inflammatory conditions, Common inflammation symptoms, CBD side effects, Treating inflammation
- Cannabidiol (CBD) Pre-Review Report. (2017, November). Retrieved from https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf
- Diabetes. (2018, August 08). Retrieved June 28, 2020, from https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444
- Cardiovascular diseases (CVDs). (n.d.). Retrieved June 28, 2020, from https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
- Berg, A. H., & Sherer, P. E. (n.d.). Adipose Tissue, Inflammation, and Cardiovascular Disease. Retrieved from https://www.researchgate.net/profile/Anders_Berg2/publication/7850337_Berg_AH_Scherer_PE_Adipose_tissue_inflammation_and_cardiovascular_disease_Circ_Res_96_939-949/links/5d2592cf299bf1547ca77960/Berg-AH-Scherer-PE-Adipose-tissue-inflammation-and-cardiovascular-disease-Circ-Res-96-939-949.pdf
- O'Sullivan, S. (2016, June). An update on PPAR activation by cannabinoids. Retrieved June 28, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882496/
- (n.d.). Retrieved June 28, 2020, from https://www.arthritis.org/health-wellness/about-arthritis/understanding-arthritis/what-is-arthritis
- Nagarkatti, P., Pandey, R., Rieder, S., Hegde, V., & Nagarkatti, M. (2009, October). Cannabinoids as novel anti-inflammatory drugs. Retrieved June 28, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
- 12, J., & Buttorff, C. (2017, July 12). Chronic Conditions in America: Price and Prevalence. RAND Corporation. https://www.rand.org/blog/rand-review/2017/07/chronic-conditions-in-america-price-and-prevalence.html.
- Irritable bowel syndrome. (2018, March 17). Retrieved June 28, 2020, from https://www.mayoclinic.org/diseases-conditions/irritable-bowel-syndrome/symptoms-causes/syc-20360016
- Ruhaak LR;Felth J;Karlsson PC;Rafter JJ;Verpoorte R;Bohlin L;. (n.d.). Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated From Cannabis Sativa. Retrieved June 28, 2020, from https://pubmed.ncbi.nlm.nih.gov/21532172/
- Darkovska-Serafimovska, M., Serafimovska, T., Arsova-Sarafinovska, Z., Stefanoski, S., Keskovski, Z., & Balkanov, T. (2018, April 23). Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases. Retrieved June 28, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922297/
- Preventing CHRONIC DISEASES a vital investment. (2005). https://www.who.int/chp/chronic_disease_report/full_report.pdf.